Konrad Most began training dogs for police work in Germany, and was appointed principal of the State Breeding and Training Establishment for police dogs in Berlin, where he carried out original research into training dogs for a broad range of service tasks. At the outbreak of war in 1914 he was charged with organising and directing the use of dogs to further the war effort. He headed the Experimental Institute for Armed Forces’ Dogs during the Second World War, and afterwards ran the German Dog Farm, a centre for the training of working dogs, including assistance dogs for the blind. He played a leading role in the formation of the German Canine Research Society and Society for Animal Psychology.
His 1910 publication Training Dogs: A Manual emphasised using instinctive behavior such as the prey drive to train desired behaviors, advocated the use of compulsion and inducements, differentiated between primary and secondary reinforcers, and described shaping behaviors, chaining components of an activity, and the importance of timing rewards and punishments. The book demonstrated an understanding of the principles of operant conditioning almost thirty years before they were formally outlined by B.F. Skinner in The Behavior of Organisms. While publishers of the 2001 reprint warn that some of the "compulsive inducements" such as the switch, the spiked collar and the forced compliance are unnecessarily harsh for today’s pet dogs, the basic principles of Most’s methods are still used in police and military settings.