Resource type: Original research — open-label controlled treatment study
Publication
Line-Alice Lecru; Daniel Combarros; Eloy Castilla-Castaño; Christelle Navarro; Marie Cadiergues (2019). Treatment of Harvest Mite Infestation in Dogs Using a Permethrin 54.5% and Fipronil 6.1% (Effitix®) Topical Spot-On Formulation. Veterinary Sciences, 6(4), article 100. DOI: 10.3390/vetsci6040100
Published online: 7 December 2019.
Reading note: This is a small veterinary treatment study, not instructions for treating an individual animal. The abstract's efficacy and tolerability conclusions are the authors' findings in the reported dogs.
Author abstract
The following is the authors’ abstract, not a site-written summary. Wording is retained; paragraph structure and inline typography are formatted for this page.
Background—The study aims to assess the efficacy of a permethrin 54.5%-fipronil 6.1%-based spot-on solution in dogs naturally infested with Neotrombicula in an open-label controlled study. Methods—Ten naturally infested dogs received one drop per affected site on day (D) 0, and on D14, the rest of the pipette was applied on the skin between the shoulders. Five dogs served as sentinels. Parasite score (0–3), skin lesions (0–4), and investigator pruritus scale (0–4) were assessed on D0, D1, D14, and D28. Results—No treated dogs developed adverse reactions. Parasite score of sentinel dogs was maintained between 1.8 (D0, D1, and D28) and 2.2 (D14). In treated dogs, D0 parasite score was 2.4. It was significantly reduced from D1 (0.5; p < 0.002) to D28 (0.1; p < 0.002). The lesion score was 2.9 on D0 and D1; it was significantly reduced on D14 (0.6; p < 0.002) and D28 (0.1; p < 0.002). Similarly, investigator pruritus scale (D0, 2.2) scores significantly decreased on D14 (0.4; p < 0.004) and D28 (0.2; p < 0.002). Conclusions—The combination permethrin-fipronil appears to be well-tolerated, rapidly and durably effective in the control of localized canine harvest mite infestation.
Source and attribution
© 2019 by the authors. Reused under Creative Commons Attribution 4.0 (CC BY 4.0). The researchers named above are the publication authors; this site provides the resource presentation.
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